BDBM50121975 (6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol::CARDIOQUIN::CHEMBL1294::CIN-QUIN::DURAQUIN::QUINACT::QUINAGLUTE::QUINALAN::QUINATIME::QUINIDEX::QUINIDINE::QUINORA::US9402878, Quinidine

SMILES COc1ccc2nccc([C@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1

InChI Key InChIKey=LOUPRKONTZGTKE-LHHVKLHASA-N

Data  7 KI  95 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50121975   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novobiotic Pharmaceuticals

US Patent
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50:  1.44E+3nMpH: 7.0Assay Description:Briefly, the experiments were performed on an IonWorks™ HT instrument (Molecular Devices Corporation), which automatically performs electrophys...More data for this Ligand-Target Pair
In DepthDetails US Patent
DrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novobiotic Pharmaceuticals

US Patent
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50:  2.67E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch plate methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novobiotic Pharmaceuticals

US Patent
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50:  324nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank